Israel and Iran have exchanged a fresh wave of attacks, stoking fears of a wider conflict after Israel expanded its surprise campaign with a strike on the world's biggest gas field.
Tehran called off nuclear talks that Washington had said were the only way to halt Israel's bombing.
Meanwhile, Israeli Prime Minister Benjamin Netanyahu said the attacks were nothing compared with what Iran would see in the coming days.
Israel's military said more missiles were launched from Iran towards Israel overnight, adding it was attacking military targets in Tehran.
Early on Sunday morning, air raid sirens sounded across Jerusalem and Tel Aviv, with explosions echoing in both cities.
Several missiles were seen streaking through the sky over Tel Aviv, while interceptor rockets were launched from the ground.
Three women killed in missile strike
Israel's emergency services say the death toll for the northern city of Tamra, where a missile struck a two-storey house earlier on Sunday, has been updated to five.
And at least three people were killed in the seaside city of Bat Yam, south of Tel Aviv, emergency services said.
They were a 10-year-old boy, a 69-year-old woman and an 80-year-old woman, with a further 100 people injured.
Reuters is also reporting, quoting Israeli media, that an estimated 35 people are missing in Bat Yam, following Iranian strikes on a residential building.
So far, at least nine people in Israel have been killed and more than 300 injured since Iran launched its retaliatory attacks on Friday.
Meanwhile Iran said the Shahran oil depot in Tehran was targeted in an Israeli attack, adding the situation was under control.
It said a fire had also erupted after an Israeli attack on an oil refinery near the capital.
Israeli strikes also targeted Iran's defence ministry building in Tehran, causing minor damage, Iran's Tasnim news agency reported on Sunday.
Iran's Islamic Revolutionary Guard Corps (IRGC) said its latest wave of missiles and drones targeted Israel's energy infrastructure and facilities for fighter jet fuel production.
The armed force also warned Tehran's attacks would be "heavier and more extensive" if Israel continued its hostilities.
In a statement, the IRGC claimed Iran had "intercepted and destroyed three cruise missiles, 10 drones, and dozens of small hostile aerial vehicles" launched by Israel into the country.
Nuclear talks cancelled
US President Donald Trump had warned Iran of worse to come, but said it was not too late to halt the Israeli campaign if Tehran accepted a sharp downgrading of its nuclear program.
A round of US-Iran nuclear talks due to be held in Oman on Sunday was cancelled, with Iranian Foreign Minister Abbas Araqchi saying the discussions could not take place while Iran was being subjected to Israel's "barbarous" attacks.
Iran partially suspended production at the world's biggest gas field on Saturday after an Israeli strike caused a fire there, according to the semi-official Tasnim news agency.
The South Pars field is located offshore in Iran's southern Bushehr province and is responsible for the majority of Iran's gas production.
The Iranian oil ministry says the blaze has now been extinguished.
If confirmed, it would mark the first Israeli strikes on Iran's oil and gas sector.
[map]Fears about potential disruption to the region's oil exports had already driven up oil prices 9 per cent on Friday even though Israel spared Iran's oil and gas on the first day of its attacks.
An Iranian general, Esmail Kosari, said on Saturday that Tehran was reviewing whether to close the Strait of Hormuz controlling access to the Gulf for tankers.
Iran says scores killed
Iran said 78 people were killed on the first day of Israel's campaign, and scores more on the second, including 60 when a missile brought down a 14-storey apartment block in Tehran, where 29 of the dead were children.
Iran had launched its own retaliatory missile volley on Friday night, killing at least three people in Israel.
With Israel saying its operation could last weeks, and Mr Netanyahu urging Iran's people to rise up against their Islamic clerical rulers, fears have grown of a regional conflagration dragging in outside powers.
B'Tselem, a leading Israeli human rights organisation, said on Saturday that instead of exhausting all possibilities for a diplomatic resolution, Israel's government had chosen to start a war that puts the entire region in danger.
Tehran has warned Israel's allies that their military bases in the region would come under fire too if they helped shoot down Iranian missiles.
However, 20 months of war in Gaza and a conflict in Lebanon last year have decimated Tehran's strongest regional proxies, Hamas in Gaza and Hezbollah in Lebanon, reducing its options for retaliation.
Israel sees Iran's nuclear program as a threat to its existence and said the bombardment was designed to avert the last steps to the production of a nuclear weapon.
Tehran insists the program is entirely civilian and that it does not seek an atomic bomb.
However, the UN nuclear watchdog this week reported it had violated obligations under the global non-proliferation treaty.
Reuters
